Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer

Cancer patients often have an activated clotting system and are at increased risk for venous thrombosis. In the present study, we analyzed tissue factor (TF) expression in 4 different human pancreatic tumor cell lines for the purpose of producing derivative tumors in vivo. We found that 2 of the lin...

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Bibliographic Details
Main Authors: Wang, Jian-Guo, Geddings, Julia E., Aleman, Maria M., Cardenas, Jessica C., Chantrathammachart, Pichika, Williams, Julie C., Kirchhofer, Daniel, Bogdanov, Vladimir Y., Bach, Ronald R., Rak, Janusz, Church, Frank C., Wolberg, Alisa S., Pawlinski, Rafal, Key, Nigel S., Yeh, Jen Jen, Mackman, Nigel
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2012
Subjects:
Thrombosis and Hemostasis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369688/
https://ncbi.nlm.nih.gov/pubmed/22547577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-402156
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