Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer

Cancer patients often have an activated clotting system and are at increased risk for venous thrombosis. In the present study, we analyzed tissue factor (TF) expression in 4 different human pancreatic tumor cell lines for the purpose of producing derivative tumors in vivo. We found that 2 of the lin...

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Detalhes bibliográficos
Main Authors: Wang, Jian-Guo, Geddings, Julia E., Aleman, Maria M., Cardenas, Jessica C., Chantrathammachart, Pichika, Williams, Julie C., Kirchhofer, Daniel, Bogdanov, Vladimir Y., Bach, Ronald R., Rak, Janusz, Church, Frank C., Wolberg, Alisa S., Pawlinski, Rafal, Key, Nigel S., Yeh, Jen Jen, Mackman, Nigel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369688/
https://ncbi.nlm.nih.gov/pubmed/22547577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-402156
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