Excess of heme induces tissue factor-dependent activation of coagulation in mice

An excess of free heme is present in the blood during many types of hemolytic anemia. This has been linked to organ damage caused by heme-mediated oxidative stress and vascular inflammation. We investigated the mechanism of heme-induced coagulation activation in vivo. Heme caused coagulation activat...

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Bibliografiska uppgifter
I publikationen:Haematologica
Huvudupphovsmän: Sparkenbaugh, Erica M., Chantrathammachart, Pichika, Wang, Shaobin, Jonas, Will, Kirchhofer, Daniel, Gailani, David, Gruber, Andras, Kasthuri, Raj, Key, Nigel S., Mackman, Nigel, Pawlinski, Rafal
Materialtyp: Artigo
Språk:Inglês
Publicerad: Ferrata Storti Foundation 2015
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349268/
https://ncbi.nlm.nih.gov/pubmed/25596265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2014.114728
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