Excess of heme induces tissue factor-dependent activation of coagulation in mice

An excess of free heme is present in the blood during many types of hemolytic anemia. This has been linked to organ damage caused by heme-mediated oxidative stress and vascular inflammation. We investigated the mechanism of heme-induced coagulation activation in vivo. Heme caused coagulation activat...

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Udgivet i:Haematologica
Main Authors: Sparkenbaugh, Erica M., Chantrathammachart, Pichika, Wang, Shaobin, Jonas, Will, Kirchhofer, Daniel, Gailani, David, Gruber, Andras, Kasthuri, Raj, Key, Nigel S., Mackman, Nigel, Pawlinski, Rafal
Format: Artigo
Sprog:Inglês
Udgivet: Ferrata Storti Foundation 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349268/
https://ncbi.nlm.nih.gov/pubmed/25596265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2014.114728
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