PF4/heparin-antibody complex induces monocyte tissue factor expression and release of tissue factor positive microparticles by activation of FcγRI

Heparin-induced thrombocytopenia (HIT) is a potentially devastating form of drug-induced thrombocytopenia that occurs in patients receiving heparin for prevention or treatment of thrombosis. Patients with HIT develop autoantibodies to the platelet factor 4 (PF4)/heparin complex, which is termed the...

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Bibliografiske detaljer
Main Authors: Kasthuri, Raj S., Glover, Sam L., Jonas, William, McEachron, Troy, Pawlinski, Rafal, Arepally, Gowthami M., Key, Nigel S., Mackman, Nigel
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2012
Fag:
Thrombosis and Hemostasis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369617/
https://ncbi.nlm.nih.gov/pubmed/22394597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-359430
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