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Non–cell-autonomous hedgehog signaling promotes murine B lymphopoiesis from hematopoietic progenitors

The role of hedgehog (Hh) signaling in B lymphopoiesis has remained unclear. We observed that the proliferation of pro-B cells in stromal cocultures was impaired by interruption of Hh signaling, prompting us to investigate whether the target of Hh antagonism was intrinsic or extrinsic to the B-lymph...

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Hlavní autoři: Cooper, Christopher L., Hardy, Richard R., Reth, Michael, Desiderio, Stephen
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369680/
https://ncbi.nlm.nih.gov/pubmed/22517907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-397976
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