Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance

Diverse human cancers with poor prognosis, including many lymphoid and myeloid malignancies, exhibit high levels of Mcl-1. To explore the impact of Mcl-1 overexpression on the hematopoietic compartment, we have generated vavP-Mcl-1 transgenic mice. Their lymphoid and myeloid cells displayed increase...

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Autores principales: Campbell, Kirsteen J., Bath, Mary L., Turner, Marian L., Vandenberg, Cassandra J., Bouillet, Philippe, Metcalf, Donald, Scott, Clare L., Cory, Suzanne
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2010
Materias:
Hematopoiesis and Stem Cells
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995351/
https://ncbi.nlm.nih.gov/pubmed/20631380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-04-281071
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