A Unified Framework for Detecting Rare Variant Quantitative Trait Associations in Pedigree and Unrelated Individuals via Sequence Data

OBJECTIVES: There is great interest to sequence unrelated or pedigree samples for detecting rare variant quantitative trait associations. In order to reduce the cost of sequencing and improve power, many studies sequence selected samples with extreme traits. Existing methods for detecting rare varia...

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Bibliographic Details
Main Authors: Liu, Dajiang J., Leal, Suzanne M.
Format: Artigo
Language:Inglês
Published: S. Karger AG 2012
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369372/
https://ncbi.nlm.nih.gov/pubmed/22555759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000336293
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