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Discovery of Rare Variants via Sequencing: Implications for the Design of Complex Trait Association Studies
There is strong evidence that rare variants are involved in complex disease etiology. The first step in implicating rare variants in disease etiology is their identification through sequencing in both randomly ascertained samples (e.g., the 1,000 Genomes Project) and samples ascertained according to...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2009
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2674213/ https://ncbi.nlm.nih.gov/pubmed/19436704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000481 |
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