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A Unified Method for Detecting Secondary Trait Associations with Rare Variants: Application to Sequence Data

Next-generation sequencing has made possible the detection of rare variant (RV) associations with quantitative traits (QT). Due to high sequencing cost, many studies can only sequence a modest number of selected samples with extreme QT. Therefore association testing in individual studies can be unde...

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Detalhes bibliográficos
Main Authors: Liu, Dajiang J., Leal, Suzanne M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499373/
https://ncbi.nlm.nih.gov/pubmed/23166519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003075
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