Role of the C(8) gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity

The role of the C(8) gem-dimethyl group in the A-ring of bryostatin 1 has been examined through chemical synthesis and biological evaluation of a new analogue. Assays for biological function using U937, K562 and MV4-11 cells as well as the profiles for downregulation of PKC isozymes revealed that th...

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Bibliographic Details
Main Authors: Keck, Gary E., Poudel, Yam B., Rudra, Arnab, Stephens, Jeffrey C., Kedei, Noemi, Lewin, Nancy E., Blumberg, Peter M.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369313/
https://ncbi.nlm.nih.gov/pubmed/22579485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.04.073
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