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Role of the C(8) gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity
The role of the C(8) gem-dimethyl group in the A-ring of bryostatin 1 has been examined through chemical synthesis and biological evaluation of a new analogue. Assays for biological function using U937, K562 and MV4-11 cells as well as the profiles for downregulation of PKC isozymes revealed that th...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3369313/ https://ncbi.nlm.nih.gov/pubmed/22579485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.04.073 |
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