Isolation and Optimization of Murine IL-10 Receptor Blocking Oligonucleotide Aptamers Using High-throughput Sequencing

Interleukin-10 (IL-10) is a key suppressor of inflammation in chronic infections and in cancer. In mice, the inability of the immune system to clear viral infections or inhibit tumor growth can be reversed by antibody-mediated blockade of IL-10 action. We used a modified selection protocol to isolat...

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Detaylı Bibliyografya
Asıl Yazarlar: Berezhnoy, Alexey, Stewart, C. Andrew, Mcnamara II, James O., Thiel, William, Giangrande, Paloma, Trinchieri, Giorgio, Gilboa, Eli
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2012
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369303/
https://ncbi.nlm.nih.gov/pubmed/22434135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.18
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