Isolation and Optimization of Murine IL-10 Receptor Blocking Oligonucleotide Aptamers Using High-throughput Sequencing

Interleukin-10 (IL-10) is a key suppressor of inflammation in chronic infections and in cancer. In mice, the inability of the immune system to clear viral infections or inhibit tumor growth can be reversed by antibody-mediated blockade of IL-10 action. We used a modified selection protocol to isolat...

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Detalhes bibliográficos
Main Authors: Berezhnoy, Alexey, Stewart, C. Andrew, Mcnamara II, James O., Thiel, William, Giangrande, Paloma, Trinchieri, Giorgio, Gilboa, Eli
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369303/
https://ncbi.nlm.nih.gov/pubmed/22434135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.18
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