Isolation and Optimization of Murine IL-10 Receptor Blocking Oligonucleotide Aptamers Using High-throughput Sequencing

Interleukin-10 (IL-10) is a key suppressor of inflammation in chronic infections and in cancer. In mice, the inability of the immune system to clear viral infections or inhibit tumor growth can be reversed by antibody-mediated blockade of IL-10 action. We used a modified selection protocol to isolat...

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Bibliografski detalji
Glavni autori: Berezhnoy, Alexey, Stewart, C. Andrew, Mcnamara II, James O., Thiel, William, Giangrande, Paloma, Trinchieri, Giorgio, Gilboa, Eli
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
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Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369303/
https://ncbi.nlm.nih.gov/pubmed/22434135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.18
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