Aptamer-Targeted Attenuation of IL-2 Signaling in CD8(+) T Cells Enhances Antitumor Immunity

Immune responses elicited against cancer using existing therapies such as vaccines or immune stimulatory antibodies are often not curative. One way to potentiate antitumor immunity is to enhance the long-term persistence of anti-tumor CD8(+) T cells. Studies have shown that the persistence of activa...

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Bibliographic Details
Published in:Mol Ther
Main Authors: Rajagopalan, Anugraha, Berezhnoy, Alexey, Schrand, Brett, Puplampu-Dove, Yvonne, Gilboa, Eli
Format: Artigo
Language:Inglês
Published: American Society of Gene & Cell Therapy 2017
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363184/
https://ncbi.nlm.nih.gov/pubmed/28129128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2016.10.021
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