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DNA Sequence Variants in the Carbonyl Reductase 1 Gene (cbr1) in 7 Breeds of Canis Lupus Familiaris

The anticancer anthracyclines doxorubicin and daunorubicin are used to treat a variety of cancers in dogs. The therapeutic utility of anthracyclines is limited by the development of cardiotoxicity in some cases. The synthesis of anthracycline alcohol metabolites by carbonyl reductase 1 (CBR1) is cru...

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Autores principales: Cheng, Qiuying, Sanborn, Carrie, Ferguson, Daniel, Blanco, Javier G.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368598/
https://ncbi.nlm.nih.gov/pubmed/22614280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4238/2012.April.27.10
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