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Inhibition of Polymorphic Human Carbonyl Reductase 1 (CBR1) by the Cardioprotectant Flavonoid 7-monohydroxyethyl rutoside (monoHER)

PURPOSE: Carbonyl reductase 1 (CBR1) reduces the anticancer anthracyclines doxorubicin and daunorubicin into the cardiotoxic metabolites doxorubicinol and daunorubicinol. We evaluated whether the cardioprotectant monoHER inhibits the activity of polymorphic CBR1. METHODS: We performed enzyme kinetic...

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Bibliografiske detaljer
Main Authors: Gonzalez-Covarrubias, Vanessa, Kalabus, James L., Blanco, Javier G.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897163/
https://ncbi.nlm.nih.gov/pubmed/18449627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-008-9592-5
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