PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils

The generation of reactive oxygen species (ROS) by the nicotinamide adenine dinucleotide phosphate oxidase is an important mechanism by which neutrophils kill pathogens. The oxidase is composed of a membrane-bound cytochrome and 4 soluble proteins (p67(phox), p40(phox), p47(phox), and GTP-Rac). Thes...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Anderson, Karen E., Chessa, Tamara A. M., Davidson, Keith, Henderson, Robert B., Walker, Simon, Tolmachova, Tanya, Grys, Katarzyna, Rausch, Oliver, Seabra, Miguel C., Tybulewicz, Victor L. J., Stephens, Len R., Hawkins, Phillip T.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society of Hematology 2010
Θέματα:
Phagocytes, Granulocytes, and Myelopoiesis
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368544/
https://ncbi.nlm.nih.gov/pubmed/20813901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-275602
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