PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils

The generation of reactive oxygen species (ROS) by the nicotinamide adenine dinucleotide phosphate oxidase is an important mechanism by which neutrophils kill pathogens. The oxidase is composed of a membrane-bound cytochrome and 4 soluble proteins (p67(phox), p40(phox), p47(phox), and GTP-Rac). Thes...

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Bibliografiske detaljer
Main Authors: Anderson, Karen E., Chessa, Tamara A. M., Davidson, Keith, Henderson, Robert B., Walker, Simon, Tolmachova, Tanya, Grys, Katarzyna, Rausch, Oliver, Seabra, Miguel C., Tybulewicz, Victor L. J., Stephens, Len R., Hawkins, Phillip T.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2010
Fag:
Phagocytes, Granulocytes, and Myelopoiesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368544/
https://ncbi.nlm.nih.gov/pubmed/20813901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-275602
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