PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils

The generation of reactive oxygen species (ROS) by the nicotinamide adenine dinucleotide phosphate oxidase is an important mechanism by which neutrophils kill pathogens. The oxidase is composed of a membrane-bound cytochrome and 4 soluble proteins (p67(phox), p40(phox), p47(phox), and GTP-Rac). Thes...

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Bibliografiska uppgifter
Huvudupphovsmän: Anderson, Karen E., Chessa, Tamara A. M., Davidson, Keith, Henderson, Robert B., Walker, Simon, Tolmachova, Tanya, Grys, Katarzyna, Rausch, Oliver, Seabra, Miguel C., Tybulewicz, Victor L. J., Stephens, Len R., Hawkins, Phillip T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2010
Ämnen:
Phagocytes, Granulocytes, and Myelopoiesis
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368544/
https://ncbi.nlm.nih.gov/pubmed/20813901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-275602
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