PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils

The generation of reactive oxygen species (ROS) by the nicotinamide adenine dinucleotide phosphate oxidase is an important mechanism by which neutrophils kill pathogens. The oxidase is composed of a membrane-bound cytochrome and 4 soluble proteins (p67(phox), p40(phox), p47(phox), and GTP-Rac). Thes...

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Bibliografski detalji
Glavni autori: Anderson, Karen E., Chessa, Tamara A. M., Davidson, Keith, Henderson, Robert B., Walker, Simon, Tolmachova, Tanya, Grys, Katarzyna, Rausch, Oliver, Seabra, Miguel C., Tybulewicz, Victor L. J., Stephens, Len R., Hawkins, Phillip T.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2010
Teme:
Phagocytes, Granulocytes, and Myelopoiesis
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368544/
https://ncbi.nlm.nih.gov/pubmed/20813901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-275602
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