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The C-Terminus of Troponin T Is Essential for Maintaining the Inactive State of Regulated Actin

Striated muscle contraction is regulated by the actin binding proteins tropomyosin and troponin. Defects in these proteins lead to myopathies and cardiomyopathies. Deletion of the 14 C-terminal residues of cardiac troponin T leads to hypertrophic cardiomyopathy. We showed earlier that regulated acti...

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Autori principali: Franklin, Andrew J., Baxley, Tamatha, Kobayashi, Tomoyoshi, Chalovich, Joseph M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368147/
https://ncbi.nlm.nih.gov/pubmed/22713569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.04.037
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