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Troponin C Mutations Partially Stabilize the Active State of Regulated Actin and Fully Stabilize the Active State When Paired with Δ14 TnT

Striated muscle contraction is regulated by the actin-associated proteins tropomyosin and troponin. The extent of activation of myosin ATPase activity is lowest in the absence of both Ca(2+) and activating cross-bridges (i.e., S1-ADP or rigor S1). Binding of activating species of myosin to actin at...

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Bibliografske podrobnosti
izdano v:Biochemistry
Main Authors: Baxley, Tamatha, Johnson, Dylan, Pinto, Jose R., Chalovich, Joseph M.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6448410/
https://ncbi.nlm.nih.gov/pubmed/28530094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01092
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