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How do antigenically varying pathogens avoid cross-reactive responses to invariant antigens?

Pathogens such as trypanosomes and malaria use antigenic variation to evade immune responses and prolong the duration of infections. As pathogens typically express more than one antigen, even relatively rare conserved antigens might be expected to trigger cross-reactive immune responses capable of c...

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Bibliografski detalji
Glavni autori: Johnson, Philip L. F., Kochin, Beth F., Ahmed, Rafi, Antia, Rustom
Format: Artigo
Jezik:Inglês
Izdano: The Royal Society 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367775/
https://ncbi.nlm.nih.gov/pubmed/22438498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rspb.2012.0005
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