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Vaccination Alters the Balance between Protective Immunity, Exhaustion, Escape, and Death in Chronic Infections

While T cell-based vaccines have the potential to provide protection against chronic virus infections, they also have the potential to generate immunopathology following subsequent virus infection. We develop a mathematical model to investigate the conditions under which T cells lead to protection v...

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Détails bibliographiques
Auteurs principaux: Johnson, Philip L. F., Kochin, Beth F., McAfee, Megan S., Stromnes, Ingunn M., Regoes, Roland R., Ahmed, Rafi, Blattman, Joseph N., Antia, Rustom
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094965/
https://ncbi.nlm.nih.gov/pubmed/21411537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00166-11
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