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Impact of Epitope Escape on PD-1 Expression and CD8 T-Cell Exhaustion during Chronic Infection

During some persistent viral infections, virus-specific T-cell responses wane due to the antigen-specific deletion or functional inactivation (i.e., exhaustion) of responding CD8 T cells. T-cell exhaustion often correlates with high viral load and is associated with the expression of the inhibitory...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Blattman, Joseph N., Wherry, E. John, Ha, Sang-Jun, van der Most, Robbert G., Ahmed, Rafi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology (ASM) 2009
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668476/
https://ncbi.nlm.nih.gov/pubmed/19211743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02524-08
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