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Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment

Chronic viral infections often result in ineffective CD8 T-cell responses due to functional exhaustion or physical deletion of virus-specific T cells. However, how persisting virus impacts various CD8 T-cell effector functions and influences other aspects of CD8 T-cell dynamics, such as immunodomina...

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Detalhes bibliográficos
Main Authors: Wherry, E. John, Blattman, Joseph N., Murali-Krishna, Kaja, van der Most, Robbert, Ahmed, Rafi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC152117/
https://ncbi.nlm.nih.gov/pubmed/12663797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.8.4911-4927.2003
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