A Single Amino Acid Substitution in the Envelope Protein of Chimeric Yellow Fever-Dengue 1 Vaccine Virus Reduces Neurovirulence for Suckling Mice and Viremia/Viscerotropism for Monkeys

A chimeric yellow fever-dengue 1 (ChimeriVax-DEN1) virus was produced by the transfection of Vero cells with chimeric in vitro RNA transcripts. The cell culture supernatant was subjected to plaque purification for the identification of a vaccine candidate without mutations. Of 10 plaque-purified clo...

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Detalhes bibliográficos
Main Authors: Guirakhoo, F., Zhang, Z., Myers, G., Johnson, B. W., Pugachev, K., Nichols, R., Brown, N., Levenbook, I., Draper, K., Cyrek, S., Lang, J., Fournier, C., Barrere, B., Delagrave, S., Monath, T. P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC514991/
https://ncbi.nlm.nih.gov/pubmed/15331733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.18.9998-10008.2004
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