Molecular Basis for Attenuation of Neurovirulence of a Yellow Fever Virus/Japanese Encephalitis Virus Chimera Vaccine (ChimeriVax-JE)

A yellow fever virus (YFV)/Japanese encephalitis virus (JEV) chimera in which the structural proteins prM and E of YFV 17D are replaced with those of the JEV SA14-14-2 vaccine strain is under evaluation as a candidate vaccine against Japanese encephalitis. The chimera (YFV/JEV SA14-14-2, or ChimeriV...

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Bibliographic Details
Main Authors: Arroyo, Juan, Guirakhoo, Farshad, Fenner, Sabine, Zhang, Zhen-Xi, Monath, Thomas P., Chambers, Thomas J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC113989/
https://ncbi.nlm.nih.gov/pubmed/11134306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.2.934-942.2001
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