Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment

Chronic viral infections often result in ineffective CD8 T-cell responses due to functional exhaustion or physical deletion of virus-specific T cells. However, how persisting virus impacts various CD8 T-cell effector functions and influences other aspects of CD8 T-cell dynamics, such as immunodomina...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Wherry, E. John, Blattman, Joseph N., Murali-Krishna, Kaja, van der Most, Robbert, Ahmed, Rafi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Pathogenesis and Immunity
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152117/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12663797/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.8.4911-4927.2003
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