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The Nrf2-Inducible Antioxidant Defense in Astrocytes can be Both Up- and Down-Regulated by Activated Microglia: Involvement of p38 MAPK

The effects of microglia-conditioned medium (MCM) on the inducible Nrf2 system in astrocyte-rich cultures were investigated by determination of glutathione (GSH) levels, γglutamylcysteine ligase (γGCL) activity, the protein levels of Nrf2, Keap1, the modulatory subunit of γGCL (γGCL-M) and activated...

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Autors principals: CORREA, FERNANDO, LJUNGGREN, ELIN, MALLARD, CARINA, NILSSON, MICHAEL, WEBER, STEPHEN G., SANDBERG, MATS
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366915/
https://ncbi.nlm.nih.gov/pubmed/21351160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.21151
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