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Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: Restoring effects of inhibitors of HDACs, p38 MAPK and GSK3β

Histone deacetylase (HDAC) inhibitors have promising neuroprotective and anti-inflammatory properties although the exact mechanisms are unclear. We have earlier showed that factors from lipopolysaccharide (LPS)-activated microglia can down-regulate the astroglial nuclear factor-erythroid 2-related f...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Correa, Fernando, Mallard, Carina, Nilsson, Michael, Sandberg, Mats
פורמט: Artigo
שפה:Inglês
יצא לאור: 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341174/
https://ncbi.nlm.nih.gov/pubmed/21757005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2011.06.016
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