A Fluorescent Biosensor Reveals Conformational Changes in Human Immunoglobulin E Fc: IMPLICATIONS FOR MECHANISMS OF RECEPTOR BINDING, INHIBITION, AND ALLERGEN RECOGNITION

IgE binding to its high affinity receptor FcϵRI on mast cells and basophils is a key step in the mechanism of allergic disease and a target for therapeutic intervention. Early indications that IgE adopts a bent structure in solution have been confirmed by recent x-ray crystallographic studies of IgE...

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Detalhes bibliográficos
Main Authors: Hunt, James, Keeble, Anthony H., Dale, Robert E., Corbett, Melissa K., Beavil, Rebecca L., Levitt, James, Swann, Marcus J., Suhling, Klaus, Ameer-Beg, Simon, Sutton, Brian J., Beavil, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366799/
https://ncbi.nlm.nih.gov/pubmed/22442150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.331967
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