Conformational effects of N-glycan core fucosylation of immunoglobulin G Fc region on its interaction with Fcγ receptor IIIa

Antibody-dependent cellular cytotoxicity (ADCC) is promoted through interaction between the Fc region of immunoglobulin G1 (IgG1) and Fcγ receptor IIIa (FcγRIIIa), depending on N-glycosylation of these glycoproteins. In particular, core fucosylation of IgG1-Fc N-glycans negatively affects this inter...

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Publicado no:Sci Rep
Main Authors: Sakae, Yoshitake, Satoh, Tadashi, Yagi, Hirokazu, Yanaka, Saeko, Yamaguchi, Takumi, Isoda, Yuya, Iida, Shigeru, Okamoto, Yuko, Kato, Koichi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653758/
https://ncbi.nlm.nih.gov/pubmed/29062024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13845-8
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