Dynamic Views of the Fc Region of Immunoglobulin G Provided by Experimental and Computational Observations

The Fc portion of immunoglobulin G (IgG) is a horseshoe-shaped homodimer, which interacts with various effector proteins, including Fcγ receptors (FcγRs). These interactions are critically dependent on the pair of N-glycans packed between the two C(H)2 domains. Fucosylation of these N-glycans negati...

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Dettagli Bibliografici
Pubblicato in:Antibodies (Basel)
Autori principali: Yanaka, Saeko, Yogo, Rina, Inoue, Rintaro, Sugiyama, Masaaki, Itoh, Satoru G., Okumura, Hisashi, Miyanoiri, Yohei, Yagi, Hirokazu, Satoh, Tadashi, Yamaguchi, Takumi, Kato, Koichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6784063/
https://ncbi.nlm.nih.gov/pubmed/31544845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antib8030039
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