Physical and Functional Interaction between Ribosomal Protein L11 and the Tumor Suppressor ARF

The ARF tumor suppressor protein activates p53 in response to oncogenic stress, whereas ribosomal protein L11 induces p53 following ribosomal stress. Both proteins bind to central, albeit non-overlapping, regions of MDM2 and suppress MDM2 activity toward p53. However, it is not known whether the two...

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Hlavní autoři: Dai, Mu-Shui, Challagundla, Kishore B., Sun, Xiao-Xin, Palam, Lakshmi Reddy, Zeng, Shelya X., Wek, Ronald C., Lu, Hua
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366788/
https://ncbi.nlm.nih.gov/pubmed/22467867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.311902
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