Physical and Functional Interaction between Ribosomal Protein L11 and the Tumor Suppressor ARF

The ARF tumor suppressor protein activates p53 in response to oncogenic stress, whereas ribosomal protein L11 induces p53 following ribosomal stress. Both proteins bind to central, albeit non-overlapping, regions of MDM2 and suppress MDM2 activity toward p53. However, it is not known whether the two...

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Библиографические подробности
Главные авторы: Dai, Mu-Shui, Challagundla, Kishore B., Sun, Xiao-Xin, Palam, Lakshmi Reddy, Zeng, Shelya X., Wek, Ronald C., Lu, Hua
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2012
Предметы:
Signal Transduction
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366788/
https://ncbi.nlm.nih.gov/pubmed/22467867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.311902
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