Mycophenolic Acid Activation of p53 Requires Ribosomal Proteins L5 and L11

Mycophenolate mofetil (MMF), a prodrug of mycophenolic acid (MPA), is widely used as an immunosuppressive agent. MPA selectively inhibits inosine monophosphate dehydrogenase (IMPDH), a rate-limiting enzyme for the de novo synthesis of guanine nucleotides, leading to depletion of the guanine nucleoti...

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Bibliographic Details
Main Authors: Sun, Xiao-Xin, Dai, Mu-Shui, Lu, Hua
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430998/
https://ncbi.nlm.nih.gov/pubmed/18305114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801387200
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