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Mycophenolic Acid Activation of p53 Requires Ribosomal Proteins L5 and L11
Mycophenolate mofetil (MMF), a prodrug of mycophenolic acid (MPA), is widely used as an immunosuppressive agent. MPA selectively inhibits inosine monophosphate dehydrogenase (IMPDH), a rate-limiting enzyme for the de novo synthesis of guanine nucleotides, leading to depletion of the guanine nucleoti...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2430998/ https://ncbi.nlm.nih.gov/pubmed/18305114 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801387200 |
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