Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to Enhance CHOP Translation

In response to different environmental stresses, phosphorylation of eukaryotic initiation factor-2 (eIF2) rapidly reduces protein synthesis, which lowers energy expenditure and facilitates reprogramming of gene expression to remediate stress damage. Central to the changes in gene expression, eIF2 ph...

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Bibliografiset tiedot
Päätekijät: Palam, Lakshmi Reddy, Baird, Thomas D., Wek, Ronald C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2011
Aiheet:
Protein Synthesis and Degradation
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064149/
https://ncbi.nlm.nih.gov/pubmed/21285359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.216093
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