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An Upstream Open Reading Frame Regulates Translation of GADD34 during Cellular Stresses That Induce eIF2α Phosphorylation
Cellular stress such as endoplasmic reticulum stress, hypoxia, and viral infection activates an integrated stress response, which includes the phosphorylation of the eukaryotic initiation factor 2α (eIF2α) to inhibit overall protein synthesis. Paradoxically, this leads to translation of a subset of...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2652341/ https://ncbi.nlm.nih.gov/pubmed/19131336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806735200 |
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