An Oncogenic Role for the Phosphorylated h-Subunit of Human Translation Initiation Factor eIF3

Dysregulation of protein synthesis has been implicated in oncogenesis through a mechanism whereby “weak” mRNAs encoding proteins involved in cell proliferation are strongly translated when the protein synthesis apparatus is activated. Previous work has determined that many cancer cells contain high...

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Bibliographic Details
Main Authors: Zhang, Lili, Smit-McBride, Zeljka, Pan, Xiaoyu, Rheinhardt, Jeanette, Hershey, John W. B.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527115/
https://ncbi.nlm.nih.gov/pubmed/18544531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800956200
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