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Phosphorylation at Tyrosine 262 Promotes GADD34 Protein Turnover
In mammalian cells, metabolic and environmental stress increases the phosphorylation of the eukaryotic translational initiation factor, eIF2α, and attenuates global protein synthesis. Subsequent transcriptional activation of GADD34 assembles an eIF2α phosphatase that feeds back to restore mRNA trans...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3829162/ https://ncbi.nlm.nih.gov/pubmed/24092754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.504407 |
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