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Phosphorylation at Tyrosine 262 Promotes GADD34 Protein Turnover

In mammalian cells, metabolic and environmental stress increases the phosphorylation of the eukaryotic translational initiation factor, eIF2α, and attenuates global protein synthesis. Subsequent transcriptional activation of GADD34 assembles an eIF2α phosphatase that feeds back to restore mRNA trans...

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Hlavní autoři: Zhou, Wei, Jeyaraman, Krishna, Yusoff, Permeen, Shenolikar, Shirish
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829162/
https://ncbi.nlm.nih.gov/pubmed/24092754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.504407
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