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Ribosome Elongation Stall Directs Gene-specific Translation in the Integrated Stress Response
Upon exposure to environmental stress, phosphorylation of the α subunit of eIF2 (eIF2α-P) represses global protein synthesis, coincident with preferential translation of gene transcripts that mitigate stress damage or alternatively trigger apoptosis. Because there are multiple mammalian eIF2 kinases...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4813566/ https://ncbi.nlm.nih.gov/pubmed/26817837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.705640 |
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