Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response

In the integrated stress response, phosphorylation of eIF2α (eIF2α-P) reduces protein synthesis to conserve resources and facilitate preferential translation of transcripts that promote stress adaptation. Preferentially translated GADD34 (PPP1R15A) and constitutively expressed CReP (PPP1R15B) functi...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Young, Sara K., Willy, Jeffrey A., Wu, Cheng, Sachs, Matthew S., Wek, Ronald C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Protein Synthesis and Degradation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653682/
https://ncbi.nlm.nih.gov/pubmed/26446796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.693184
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