Selective mRNA translation during eIF2 phosphorylation induces expression of IBTKα

Disruption of protein folding in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR), a transcriptional and translational control network designed to restore protein homeostasis. Central to the UPR is PKR-like ER kinase (PERK/EIF2AK3) phosphorylation of the α subunit of eIF2...

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Main Authors: Baird, Thomas D., Palam, Lakshmi Reddy, Fusakio, Michael E., Willy, Jeffrey A., Davis, Christopher M., McClintick, Jeanette N., Anthony, Tracy G., Wek, Ronald C.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019499/
https://ncbi.nlm.nih.gov/pubmed/24648495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-02-0704
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