Membrane-Microdomain Localization of Amyloid β-Precursor Protein (APP) C-terminal Fragments Is Regulated by Phosphorylation of the Cytoplasmic Thr(668) Residue

Amyloid β-precursor protein (APP) is primarily cleaved by α- or β-secretase to generate membrane-bound, C-terminal fragments (CTFs). In turn, CTFs are potentially subject to a second, intramembrane cleavage by γ-secretase, which is active in a lipid raft-like membrane microdomain. Mature APP (N- and...

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Hlavní autoři: Matsushima, Takahide, Saito, Yuhki, Elliott, James I., Iijima-Ando, Kanae, Nishimura, Masaki, Kimura, Nobuyuki, Hata, Saori, Yamamoto, Tohru, Nakaya, Tadashi, Suzuki, Toshiharu
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366005/
https://ncbi.nlm.nih.gov/pubmed/22511769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.334847
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