ISCOMATRIX vaccines mediate CD8(+) T-cell cross-priming by a MyD88-dependent signaling pathway

Generating a cytotoxic CD8(+) T-cell response that can eradicate malignant cells is the primary objective of cancer vaccine strategies. In this study we have characterized the innate and adaptive immune response to the ISCOMATRIX adjuvant, and the ability of vaccine antigens formulated with this adj...

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Detaylı Bibliyografya
Asıl Yazarlar: Wilson, Nicholas S, Yang, Becky, Morelli, Adriana Baz, Koernig, Sandra, Yang, Annie, Loeser, Stefanie, Airey, Denise, Provan, Larissa, Hass, Phil, Braley, Hal, Couto, Suzana, Drane, Debbie, Boyle, Jeff, Belz, Gabrielle T, Ashkenazi, Avi, Maraskovsky, Eugene
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2012
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365289/
https://ncbi.nlm.nih.gov/pubmed/21894173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2011.71
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