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B Cell-Specific S1PR1-Deficiency Blocks Prion Dissemination Between Secondary Lymphoid Organs()

Many prion diseases are peripherally acquired (eg. orally or via lesions to skin or mucous membranes). After peripheral exposure prions replicate first upon follicular dendritic cells (FDC) in the draining lymphoid tissue before infecting the brain. However, after replication upon FDC within the dra...

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Detalhes bibliográficos
Main Authors: Mok, Simon W.F., Proia, Richard L., Brinkmann, Volker, Mabbott, Neil A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3364719/
https://ncbi.nlm.nih.gov/pubmed/22504650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200349
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