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Oral Prion Neuroinvasion Occurs Independently of PrP(C) Expression in the Gut Epithelium

The early replication of certain prion strains within Peyer's patches in the small intestine is essential for the efficient spread of disease to the brain after oral exposure. Our data show that orally acquired prions utilize specialized gut epithelial cells known as M cells to enter Peyer'...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Virol
Prif Awduron: Marshall, Alison, Bradford, Barry M., Clarke, Alan R., Manson, Jean C., Mabbott, Neil A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146811/
https://ncbi.nlm.nih.gov/pubmed/30021891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01010-18
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