Follicular Dendritic Cell-Specific Prion Protein (PrP(c)) Expression Alone Is Sufficient to Sustain Prion Infection in the Spleen

Prion diseases are characterised by the accumulation of PrP(Sc), an abnormally folded isoform of the cellular prion protein (PrP(C)), in affected tissues. Following peripheral exposure high levels of prion-specific PrP(Sc) accumulate first upon follicular dendritic cells (FDC) in lymphoid tissues be...

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Detalhes bibliográficos
Main Authors: McCulloch, Laura, Brown, Karen L., Bradford, Barry M., Hopkins, John, Bailey, Mick, Rajewsky, Klaus, Manson, Jean C., Mabbott, Neil A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228802/
https://ncbi.nlm.nih.gov/pubmed/22144895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002402
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