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Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1

An unresolved issue about many neurodegenerative diseases is why neurons are particularly sensitive to defects in ubiquitous cellular processes. One example is Niemann Pick type C1, caused by defects in cholesterol trafficking in all cells, but where neurons are preferentially damaged. Understanding...

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Autors principals: Ordonez, M. Paulina, Roberts, Elizabeth A., Kidwell, Chelsea U., Yuan, Shauna H., Plaisted, Warren C., Goldstein, Lawrence S.B.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3363339/
https://ncbi.nlm.nih.gov/pubmed/22437840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds090
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